The Tribunal of the Holy Office of the Inquisition (Spanish: Tribunal del Santo Oficio de la Inquisición), commonly known as the Spanish Inquisition (Inquisición española), was established in 1478 by Catholic MonarchsFerdinand II of Aragon and Isabella I of Castile. It was intended to maintain Catholic orthodoxy in their kingdoms and to replace the Medieval Inquisition, which was under Papal control. It became the most substantive of the three different manifestations of the wider Catholic Inquisition along with the Roman Inquisition and Portuguese Inquisition. The “Spanish Inquisition” may be defined broadly, operating in Spain and in all Spanish colonies and territories, which included the Canary Islands, the Kingdom of Naples,[citation needed] and all Spanish possessions in North, Central, and South America. According to modern estimates, around 150,000 were prosecuted for various offenses during the three-century duration of the Spanish Inquisition, out of which between 3,000 and 5,000 were executed (~2.7% of all cases).

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